Pharmacology and Toxicology

Adult killifish exposure to crude oil perturbs embryonic gene expression and larval morphology in first- and second-generation offspring
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librarian
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Helix-8 and Carboxyl Terminal Tail Regulation of Proteinase Activated Receptor-4 (PAR4) signalling
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Rithwik Ramachandran
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Combinatorial effects of Zingiber officinale and Citrus limon juices: Hypolipidemic and antioxidant insights from in vivo, in vitro, and in silico investigations
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Oussama Bekkouch
3 views
TLR4 Modulates Simvastatin's Impact on HDL Cholesterol and Glycemic Control
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librarian
4 views
Binding Affinity Ranking at the Molecular Initiating Event (BARMIE): An open-source computational pipeline for ecological hazard ranking of endocrine disrupting chemicals.
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librarian
3 views
Cryo-EM reveals a new allosteric binding site at the M5 mAChR
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librarian
6 views
High-content morphological profiling by Cell Painting in 3D spheroids.
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librarian
10 views
Conditioned versus innate effort-based tasks reveal divergence in antidepressant effect on motivational state in male mice
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librarian
4 views
Formyl-peptide receptor type 2 activation mitigates secondary organ damage in inflammatory arthritis
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Mauro Perretti
7 views
Cytochrome P450 inhibition impedes pyrethroid effects on insects through Nav channel regulation
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Beata Niklas
9 views
From discovery to translation: Endogenous substrates of OAT1 and OAT3 as clinical biomarkers for renal secretory function
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librarian
4 views
Mechanistic modeling suggests stroma-targeting antibody-drug conjugates as an alternative to cancer-targeting in cases of heterogeneous target expression
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librarian
4 views
Chronic Inhaled Benzene Exposure Exacerbates Atherosclerosis in LDL Receptor-Knockout Mice
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Sanjay Srivastava
3 views
A small lipidated peptide targeting NaV1.8 channels attenuates osteoarthritic pain behavior and prevents bone erosion
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librarian
3 views
Fluorescence Lifetime Imaging Microscopy (FLIM) visualizes internalization and biological impact of nanoplastics in live intestinal organoids
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librarian
3 views
Cellular and mitochondrial effects of a gold-N Heterocyclic Carbene on LNCaP and PC3 prostate cancer cell lines
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librarian
5 views
Lipidomic Analysis Reveals Drug-Induced Lipoxins in Glaucoma Treatment
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librarian
7 views
Rhamnose-mediated modulation of hair follicle growth: insights from chemical genomics
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Ran Xiao
4 views
Increased RAMP3 expression enhances GLP-1 mediated Glucose Stimulated Insulin Secretion in a Manner Dependent on Ca2+ Mobilisation
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librarian
3 views
Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophy
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librarian
4 views
From Toxicogenomics Data to Cumulative Assessment Groups: A Mechanistic Framework for Chemical Grouping
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librarian
5 views
The Lipidome Landscape of Amiodarone Toxicity: An in vivo Lipid-centric Multi-Omics Study
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librarian
5 views
Does repeated administration of baclofen in free feeding rats reduce body weight by stimulating brown fat metabolism through activation of the sympathetic nervous system?
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librarian
13 views
Antisense Oligonucleotide Quantification via Splint-Ligation PCR Assay in Non-Human Primate Central Nervous System Tissues and Biofluids
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librarian
7 views
Free acid β-hydroxybutyrate supplementation does not ameliorate dextran sodium sulfate-induced colitis similar to ketogenic diet in male mice
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librarian
4 views
Enantioselective Protein Affinity Selection Mass Spectrometry (EAS-MS)
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Hui Peng
11 views
Improving the Safety of N,N-Dimethylacetamide (DMA) as a Potential Treatment for Preterm Birth in a Pregnant Mouse Model Using a Vaginal Nanoformulation
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librarian
4 views
N,N-dimethylacetamide blocks inflammation-induced preterm birth and remediates maternal systemic immune responses
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Sandra Reznik
12 views
In vitro Activity of Citrus IntegroPectin against Lung Cancer Cells
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librarian
6 views
Mechanistic Insights into Sphingomyelin Nanoemulsions as Drug Delivery Systems for Non-Small Cell Lung Cancer Therapy
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librarian
5 views
Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001
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librarian
5 views
Defining the Polycystin Pharmacophore Through HTS & Computational Biophysics.
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Paul DeCaen
4 views