Pharmacology and Toxicology

Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis

Rapid, open-source, and automated quantificati...

Pharmacology and Toxicology
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Grant Glatfelter
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Cortical reactive microglia activate astrocytes, increasing neurodegeneration in human alcohol use disorder

Cortical reactive microglia activate astrocyte...

Pharmacology and Toxicology
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Fulton Crews
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Nanotechnology-Driven Synergy: Research Effects of Curcumin Nanosuspension and Fluconazole Combination in Overcoming Azole Resistance in Candida Albicans

Nanotechnology-Driven Synergy: Research Effect...

Pharmacology and Toxicology
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Cheng Zhang
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Exploring Phage-Staphylococcus aureus Host Dynamics Through Innovative In Vitro Experiment and Pharmacokinetic/pharmacodynamic Modeling

Exploring Phage-Staphylococcus aureus Host Dyn...

Pharmacology and Toxicology
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librarian
1 view
RSPO2-based peptibodies conjugated with pyrrolobenzodiazepine dimer or camptothecin analogs demonstrate potent anti-tumor activity by targeting the three receptors LGR4/5/6

RSPO2-based peptibodies conjugated with pyrrol...

Pharmacology and Toxicology
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librarian
0 views
An Enantioselective Chemical Probe for Chikungunya nsP2 Helicase with Antialphaviral Activity

An Enantioselective Chemical Probe for Chikung...

Pharmacology and Toxicology
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librarian
1 view
Cannabidiol Reduces Oxycodone Self-Administration While Preserving Its Analgesic Efficacy in a Rat Model of Neuropathic Pain

Cannabidiol Reduces Oxycodone Self-Administrat...

Pharmacology and Toxicology
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librarian
6 views
On-cell Saturation Transfer Difference (STD) NMR on ion channels: characterizing negative allosteric modulator binding interactions of P2X7.

On-cell Saturation Transfer Difference (STD) N...

Pharmacology and Toxicology
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Serena Monaco
5 views
G protein-coupled receptor 35 (GPR35) stimulation reduces osteoclast activity in primary human bone cells

G protein-coupled receptor 35 (GPR35) stimulat...

Pharmacology and Toxicology
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librarian
4 views
Peptide-functionalized fluorescent polymeric nanoparticles: polysarcosine length defines stealth properties

Peptide-functionalized fluorescent polymeric n...

Pharmacology and Toxicology
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librarian
1 view
Exploring Effective Ingredients and Potential Mechanisms of Stem Cell-derived Dendrobium Officinale Extract in Treatment of Allergic Rhinitis

Exploring Effective Ingredients and Potential ...

Pharmacology and Toxicology
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librarian
2 views
A Lipid Prodrug Strategy Enhances Targeted Protein Degrader CNS Pharmacokinetics

A Lipid Prodrug Strategy Enhances Targeted Pro...

Pharmacology and Toxicology
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librarian
2 views
Exploring the mechanism of kaji-ichigoside F1 on bacterial pneumonia based on the network pharmacology and transcriptome

Exploring the mechanism of kaji-ichigoside F1 ...

Pharmacology and Toxicology
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librarian
8 views
Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor

Antimuscarinic drugs exert β-arrestin-biased a...

Pharmacology and Toxicology
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librarian
7 views
Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay

Design of peptide-based PAC1 antagonists combi...

Pharmacology and Toxicology
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librarian
7 views
Evaluation of cytotoxic effects of diverse essential oils on human keratinocytes (HaCaT)

Evaluation of cytotoxic effects of diverse ess...

Pharmacology and Toxicology
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librarian
8 views
CERIUM OXIDE NANOPARTICLES ATTENUATE THE PRO-ARRHYTHMIC EFFECT OF DIESEL EXHAUST PARTICLES IN ISOLATED RAT HEARTS BY REDUCING OXIDATIVE STRESS.

CERIUM OXIDE NANOPARTICLES ATTENUATE THE PRO-A...

Pharmacology and Toxicology
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Antonio Rodríguez-Sinovas
12 views
Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells

Photodisruption of the inner limiting membrane...

Pharmacology and Toxicology
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Emma De Coster
7 views
DICAR-JP Regulates Ribosome Migration, a New Theory of Mitochondrial Protein Production

DICAR-JP Regulates Ribosome Migration, a New T...

Pharmacology and Toxicology
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librarian
8 views
Animal product-free formation and cultivation of 3D primary hepatocyte spheroids

Animal product-free formation and cultivation ...

Pharmacology and Toxicology
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Maria Karlgren
11 views
Accelerated plastic aging in suspension (APAS): A simple, reproducible approach for the generation of model micro- and nanoplastics through simulated environmental forces

Accelerated plastic aging in suspension (APAS)...

Pharmacology and Toxicology
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librarian
12 views
ArcDFI: Attention Regularization guided by CYP450 Interactions for Predicting Drug-Food Interactions

ArcDFI: Attention Regularization guided by CYP...

Pharmacology and Toxicology
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Donghyeon Park
9 views
Sevoflurane inhibition of the developmentally expressed neuronal sodium channel Nav1.3

Sevoflurane inhibition of the developmentally ...

Pharmacology and Toxicology
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Jiaxin Xiang
8 views
Assessing the potential cardiovascular risk of microdosing the psychedelic LSD in mice

Assessing the potential cardiovascular risk of...

Pharmacology and Toxicology
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librarian
8 views
Andrographolide prevents necroptosis by suppressing generation of reactive oxygen species

Andrographolide prevents necroptosis by suppre...

Pharmacology and Toxicology
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librarian
10 views
A Precision Gene Engineered B Cell Medicine Producing Sustained Levels of Active Factor IX for Hemophilia B Therapy

A Precision Gene Engineered B Cell Medicine Pr...

Pharmacology and Toxicology
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librarian
11 views
treecompareR: Tree Visualizations of Chemical Space

treecompareR: Tree Visualizations of Chemical ...

Pharmacology and Toxicology
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librarian
8 views
TMT-based quantitative proteomic assessment of Vicia sativa induced neurotoxicity by β-cyano-L-alanine and γ-glutamyl-β-cyano-L-alanine in SH-SY5Y cells.

TMT-based quantitative proteomic assessment of...

Pharmacology and Toxicology
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Iain Searle
12 views
A Cheminformatics Workflow for Higher-throughput Modeling of Chemical Exposures from Biosolids

A Cheminformatics Workflow for Higher-throughp...

Pharmacology and Toxicology
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librarian
9 views
Structure-Based Classification of CRISPR/Cas9 Proteins: A Machine Learning Approach to Elucidating Cas9 Allostery

Structure-Based Classification of CRISPR/Cas9 ...

Pharmacology and Toxicology
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librarian
17 views
The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation

The non-steroidal mineralocorticoid receptor (...

Pharmacology and Toxicology
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Moshe Levi
12 views
PAC: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

PAC: A novel translational concordance framewo...

Pharmacology and Toxicology
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Lyndsey Anderson
13 views
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