Sterben, S. P.; Anamala, C. C.; Koduri, V.; Kansakar, S. B.; Liaudanskaya, V.

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by impaired social interactions, repetitive behaviors, and disrupted neuronal circuit maturation. Emerging evidence implicates both microglial function and mitochondrial regulation as critical determinants of ASD pathogenesis. Here, we identified microglia and their mitochondria as active modulators of neuronal circuit development, highlighting their potential roles as mechanistic contributors and biomarkers in ASD progression.