Marino-Ramirez, L.; Sharma, S.; Hamilton, J. M.; Nguyen, T. L.; Gupta, S.; Natarajan, A. V.; Nagar, S. D.; Menuey, J. L.; Chen, W.-A.; Sanchez-Gomez, A.; Satizabal-Soto, J. M.; Martinez, B.; Marrugo, J.; Medina-Rivas, M.; Gallo, J. E.; Jordan, I. K.; Valderrama-Aguirre, A.

The Consortium for Genomic Diversity, Ancestry, and Health in Colombia (CODIGO) aims to build a community of Colombian researchers in support of local capacity in genomics, bioinformatics, and precision health. Here, we present the first CODIGO data release and the consortium web platform, including annotations for more than 95 million genetic variants from 1,441 samples representing 14 populations from across the country. CODIGO samples show a wide range of African (16.7%), European (50.6%), and Indigenous American (32.8%) genetic ancestry components, with five distinct ancestry clusters. Thousands of ancestry-enriched variants, with divergent allele frequencies across clusters, show pharmacogenomic and clinical genetic associations. Examples include African ancestry-enriched variants associated with fast metabolism of the immunosuppressive drug tacrolimus and malaria resistance and European ancestry-enriched variants associated with nicotine dependence and hereditary hemochromatosis. CODIGO reveals the nexus between ancestry and health in Colombia and underscores the utility of collaborative genome sequence analysis efforts.